Eurasian Medical Journal

International Higher School of Medicine

ISSN 1694-8254

INFLUENCE OF GREEN TOBACCO ON CHILD DEVELOPMENT AND LOCAL PROTECTIVE MECHANISMS

Belov G.V.1,2, Zakirova T.A.1, Talantbekova N. T.2

Abstract
Introduction. In the tobacco-growing farms of Kyrgyzstan, work with green leaves and dried tobacco raw materials is mostly done on home plots by women of reproductive age. Children of middle and high schools are attracted to the production. Preschoolers and junior schoolchildren are for a long time with mothers employed in production. 


Chemical pleurodesis using betadine and glucose in the treatment of patients with transudative pleural effusion in case of chronic kidney disease

A.A. Egay1, 2, B. Kh. Bebezov¹, A.T. Kazakbaev¹, A.E. Tentimishev², A.M. Feigin3

Abstract
Transudative pleural effusion (PE) is most often encountered in patients with congestive heart failure, hepatic and renal failure, and especially in their terminal stages, as an indicator of the decompensation of the patient's condition. Chemical pleurodesis (CP) has been successfully used for several decades in patients with malignant PE, both with primary lesion of the pleura, and with its secondary lesion. The choice of an agent for pleurodesis should be based on its effectiveness, safety and availability. Despite the extensive study of this issue, the search for the ideal pleurosclerosant is still underway. 


Quality of life of patients with the lower extremities varicose veins

V. N. Nikolenko1,2, I. A. Vinokurov1, S. N. Odinokova1, G. V. Mnatsakanyan1, R. Kh. Belkharoeva1

Abstract
Introduction. The wide prevalence of the lower extremities varicose veins and the variety of methods for its surgical correction, necessitate a comparative assessment of the quality of life of patients after various methods of surgical treatment. 
The aim is to assess the quality of life of patients with the lower extremities varicose veins, depending on the surgical treatment method.


THE ROLE OF ACTIVATION OF SOLUBLE TUMOR NECROSIS FACTOR-Α RECEPTORS IN THE DEVELOPMENT OF COMORBID PATHOLOGY: CHRONIC HEART FAILURE ASSOCIATED WITH TYPE 2 DIABETES AND OSTEOPOROSIS

Shilov S.N.1, Berezikova E.N.1, Uzakov O.J4., Samsonova E.N.1, Safronov I.D.1, Popova A.A.1, Yakovleva I.V.1, Efremov A.V.2, Schmidt G.2,Teplyakov A.T.3, Grakova E.V.3

Abstract
Objective. To study the clinical and pathogenetic relationship between the risk of developing heart failure (CHF), type 2 diabetes mellitus (DM), and osteoporosis with the level of activation of soluble tumor necrosis factor-α 1 and type 2 receptors (TNF-α-SR1 and SR2) and osteoprotegerin, as well as to evaluate the effectiveness of bisphosphonate therapy in postmenopausal women.


ARTERIAL HYPERTENSION IN DIABETES MELLITUS TYPE 2 AND THE EXPERIENCE OF USING «ROTAZAR"

R. B. Sultanalieva1, V. G. Knyazeva1, K. B. Jooshbaev2, D. M. Satarova2, N. N. Usubaliev1.

Abstract 
Angiotensin-converting enzyme (ACE) inhibitors and type 1 angiotensin receptor blockers (ARBS) can slow the progression of nephropathy and provide regression of albuminuria and proteinuria in diabetes mellitus (DM). Effective reduction of blood pressure in patients with DM is no less significant for reducing the risk of complications than careful control of glycemia. Achieving the target blood pressure (BP) is one of the strategies for preventing cardiovascular complications in patients with diabetes.


STATE OF IMMUNE REACTIVITY IN EXPERIMENTAL ANIMALS WITH CARCINOSARCOMA WALKER 256 EXPOSED TO GENERAL HYPERTHERMIA

E.A. Vaskina1, O.Zh. Uzakov2, A.V. Efremov1

Abstract
The paper presents immunity indicators in rats with Walker 256 carcinosarcoma during the development of the tumor process and exposure to general hyperthermia. The data obtained indicate that the effect of general hyperthermia on the body of experimental animals with Walker 256 carcinosarcoma is accompanied by multidirectional changes in the parameters of the immune system both in the direction of their decrease and increase in various periods after hyperthermia. This may be due to the activation of endogenous regulatory systems that determine the body's immune reactivity.
Keywords: Walker 256 carcinosarcoma, humoral and cellular immunity, general hyperthermia.


EVALUATION OF THE EFFECTIVENESS OF ABSOLUTELY DRAINLESS PERCUTANEOUS NEPHROLITHOTRIPSY

F.Yu. Yuldashev1, F.R. Nasirov1, J.Kh. Mirkhamidov1

Abstract
The presence of drains in the urinary tract, installed in percutaneous nephrolithotripsy, is fraught with a number of complications and causes inconvenience for the patient. Absolutely drainless percutaneous nephrolithotripsy can significantly reduce the incidence of catheter-associated urinary tract infection, reduce the need for analgesics in the postoperative period, and reduce the length of hospital stay and the cost of medical services.
Key words: urolithiasis, endoscopic treatment, complications.


Materials of IV International Interinstitutional Science and Practice Conference on “Innovations in medical science and education” October 23-24, 2020, International Higher School of Medicine, Bishkek, Kyrgyzstan Annex to the 1st number of Eurasian Medica

The research work of students

The research work of students is one of the most important means of improving the quality of training of specialists with higher education, who are able to creatively apply the achievement of scientific progress in practice.


FREQUENCY AND POSSIBLE CAUSES OF BILIARY DYSKINESIA IN PATIENTS WITH BRONCHIAL ASTHMA IN THE KYRGYZ REPUBLIC

M.E. Asheraliev1, A.T. Alymkulov2, Gupta Richa2

Abstract
The article shows the essential component of biliary dyskinesia (BAD) frequency in a sample of patients with bronchial asthma. The data on dysfunctions of the gastrointestinal tract at the subclinical level of manifestations and a comparative characteristic external respiration functions between patients with DVP in the subclinical course and the period of remission are presented.
Key words: bronchial asthma, DVP, FVD, gastroduodenal pathology.


HISTORY OF DEVELOPMENT AND STATE OF HEMODIALYSIS SERVICE IN AZERBAIJAN

Fariz G. Babaev ogly

Abstract
Currently, the most pressing medical and social health problem is the progressive growth of chronic renal failure. The organization and development of hemodialysis treatment in Azerbaijan is associated with the name of the founder of the school of urology, nephrology, hemodialysis and kidney transplantation in Azerbaijan, academician M.D. Javad-zade. For the first time in the USSR on March 4, 1958 with the participation of M.D. Javad-zade at the urology clinic of the second MOLGMI named after N.I. Pirogov, the first hemodialysis session was carried out in a patient with acute renal failure.


RESULTS OF SURGICAL TREATMENT OF BENIGN ADRENAL TUMORS

B Bebezov1, T.A. Ermekov2, A. Kydyraliev2

Abstract
The results and analysis of  the surgical treatment of 48 patients with adrenal tumors operated from 2009 to 2018 are shown. The indication for surgical treatment of adrenal gland masses is the clinical manifestation of the tumor, its hormonal activity and the high malignant potential of the tumor. Of the 48 (100%) cases of benign adrenal tumors, in most cases adenomas of the adrenal cortex - 26 (54.0%) patients. Then pheochromocytomas - 11 (23.0%), adrenal cysts - 7 (15.0%), adrenal hyperplasia - 3 (6.0%) and myelolipomas - 1 (2%). The laparotomic approach is the most convenient, effective and sparing approach, which improves the patient's quality of life in the postoperative period than the thoracoabdominal and translumbar approaches.
Key words: adrenal tumor, adrenalectomy.


PALLIATIVE PERCUTANEOUS TRANSHEPATIC INTERVENTIONS IN COMPLICATED LIVER ALVEOCOCCOSIS

Turar A. Yermekov , Shamil M. Chingyshpayev

Abstract
Introduction. The article presents the experience of transcutaneous transhepatic drainage of the decay cavity in complicated liver alveococcosis. This intervention was used in the complex of both palliative care and in the preparation of the patient for radical surgical intervention. The results of the treatment of 20 patients with complicated liver alveococcosis are reflected. The effectiveness of transcutaneous transhepatic interventions to facilitate patients' condition and/or prepare them for extensive surgical operations compared to open methods of drainage of alveococcal caverns has been shown.


COMPARATIVE CHARACTERISTICS OF THE FREQUENCY AND LEVEL OF ANXIETY DISORDERS AMONG RESPONDENTS LIVING IN KYRGYZSTAN AND KAZAKHSTAN DURING THE COVID -19 PANDEMIC

O. Zh. Uzakov, S.Yu. Komissarova, A.T. Alymkulov, Kermaly kyzy M.

Abstract
Introduction. At present COVID-19 pandemic is an acute and socially significant problem for the whole world population, which is explained by its scale, contagiousness, the insidiousness of the pathogen, and lack of effective preventive means (vaccine) and effective therapeutic ways to combat this infection. It is safe to say that one of the main parameters of Covid-19 pandemic evaluation is the psycho-emotional and psychological health of the population


GLAUCOMA AS A SOCIALLY SIGNIFICANT EYE DISEASE AMONG ADULTS AND CHILDREN UNDER 14

Omorova G.K.

Abstract
Introduction. Glaucoma is one of the leading causes of irreversible vision loss, so it is one of the pressing problems of modern healthcare. According to WHO, glaucoma accounts for up to 5% of all ocular pathology. By 2020, the number of patients will increase to 5.9 million and 5.3 million will lose vision due to primary glaucoma. Among the causes of primary disability, glaucoma has remained stable at a fairly high level for many years, amounting to 20-28%. 


MORPHOLOGICAL FEATURES OF THE SOMATOTYPE OF FOREIGN AND LOCAL STUDENTS

Nurgul K. Omuralieva1, Aigul A. Chonkoeva1

Abstract
Introduction. It is well known that one of the main criteria of health is the adaptive capacity of the body and physical development. The geoclimatic distribution of various populations in the usual living conditions leaves certain imprints on cultural traits, morphological and physiological characteristics of the organism's vital activity. 


ECHINOCOCCOSIS OF THE PERICARDIUM (CASE FROM PRACTICE)

I.H. Bebezov, A.A. Rakimbaev, M.K. Dzhundubaev, D.B. Toktosunova, E.D. Seitahunova, R.S. Kalieva, A.K. Turgunov

Abstract

Echinococcosis is a parasitic disease widespread in many countries of the world and continues to remain a serious medical and national economic problem. The article presents a rare case of a giant echinococcal cyst localized in the pericardial cavity with invasion into the left ventricular myocardium and causing compression of the left heart, as well as surgical intervention aimed at its complete removal.


ASSESSMENT OF THE PLASMA LIPID SYSTEM ADAPTIVE STRATEGIES BY DIFFERENTIAL ENTROPY MODELING USE

Chonkoeva A.A., Mukhamedova I.P.

Abstract

Introduction. The lipid system of the blood is an example of a dynamic, open thermodynamic, stochastic system, which includes the following components: lipoproteins containing triacylglycerides, cholesterol and cholesterol esters, the state of which can be described by an entropy value and thus characterize the state of the like system as a whole.


POSSIBILITIES OF SURGICAL APPROACHES TO REMOVE TUMORS OF THE PARANASAL SINUSES THAT HAVE SPREAD TO THE BASE OF THE SKULL

A.M.Orozalieva1, B.D.Shalabaev2, Ali Zeshan1, Zeeshan Majeed1

Abstract

Introduction. Surgical treatment of tumors of the paranasal sinuses that have spread to the base of the skull, include those with invasion into the cranial fossa, belonging to a severe and often dangerous category and fraught with serious complications. Therefore, the choice of a surgical approach to remove such tumors is of particular importance.


HISTOSTRUCTURE OF INTRAMURAL LYMPHOID FORMATIONS OF THE HEART

Masalbek A. Satybaldiev1, Aida M. Ergesheva2, Adelya E. Seytkulova1

Abstract

The system intraorganic Structures I lymphatic collectors of the heart, their size, structure and location in time of personal areas of wall lymphangions . Generation and configuration of muscle fibers in the structure of the uniting vessel. A diagram of the connection of various structures of the lymphatic system for the implementation of the passage of lymph, from the subendocardial lymphatic capillaries to the main vessels of the outflow.

Key words: lymphangion, lymphatic bed, collector, caliber, shape.


CLINICAL CASE RARE COMBINATIONS PRIMARY HYPERPARATHYROIDISM WITH DEFICIENCY OF VITAMIN D

Sultanalieva R.B., Knyazeva V.G., Kudaibergenova N.T.

Abstract

Primary hyperparathyroidism is a rare but interesting pathology that affects not only the parathyroid glands, but also bones, kidneys, and other organs. This pathology is rarely diagnosed at an early stage. We have given an example of an unusual combination of primary hyperparathyroidism and vitamin D deficiency.

Key words: Parathyroid gland, vitamin D, hormones, calcium.


THE EFFECTIVENESS OF COMPLEX THERAPY FOR THE REGENERATION OF POSTOPERATIVE WOUNDS (EXPERIMENTAL STUDY)

T.B. Uzakov

Abstract

Summary: The study was carried out on 60 white Wistar rats, simulating a surgical wound. The rats were divided into 5 groups of 10 rats each. Group 1 is control - rats from this group were made an incision on the sidewall, abdominal wall, followed by natural healing within 10 days; Group 2 - an incision followed by the use of chitosan ointment; Group 3 - the wound was exposed to photostimulation treated with methylene blue; Group 4 - physical activity in the postoperative period on a treadmill for 30 minutes; Group 5 - complex application of chitosan, photostimulation, and physical activity. Wound healing was recorded by determining the area, photo-fixation of the wound, and histological examinations of the skin and internal organs were performed.


DEVELOPMENT OF A METHOD FOR ENDOSCOPIC RECANALIZATION OF THE URETHRA

Faizulla Yu. Yuldashev1, Furkat R. Nasirov1, Jalal Kh. Mirkhamidov1, Safojon S. Kasimov2, Muhammadzarif K. Bakhadirkhanov2, Nozima J. Uralova2

Abstract

The article summarizes the results of the analysis of data from the treatment of 53 atients who underwent endoscopic recanal ization of obl iterated urethra, fol lowed by electric esection scar tissue. Conducted cl inical studies  have shown that recurrences, after the ntervention, by the end of 1 year of observation, occur in 18.9% of patients.

Key words: obliteration of the urethra, endoscopic treatment, efficacy.


CHARACTERISTICS OF OPPORTUNISTIC INFECTIONS IN THE BLOOD OF PREGNANT WOMEN AND NEWBORNS

G.U. Asymbekova, A.O. Atykanov, O.Zh. Uzakov, Ya.V. Ten

Abstract
The article presents data from a survey of 166 pregnant women and 67 newborns at the "Clinic of Professor G.U. Asymbekova" for the period 2019-2020, for the presence of opportunistic infections in the blood serum. 1340 studies were carried out to determine rubella, toxoplasma, cytomegalovirus (CMV), herpes simplex virus (HSV) types 1 and 2, chlamydia - trachomatis, mycoplasma - hominis, ureaplasma - urealyticum, trichomonas - vaginalis by enzyme immunoassay (ELISA) (enzyme immunoassay) Ig) of class G, M, A by diagnostic test systems of "VEKTOR" company (Russia).
It was found that in pregnant women, infection occurred before pregnancy, and during pregnancy, there was no acute phase of infection. Positive titers of IgG antibodies and the absence of IgM antibodies in newborn babies indicate the transmission of IgG antibodies during pregnancy from the mother, as well as the absence of acute infection.
Keywords: Pregnant women, newborn children, opportunistic infections, immunoglobulins, antibodies.


TRENDS IN THE INCIDENCE AND MORTALITY OF CERVICAL CANCER IN THE KYRGYZ REPUBLIC

S.A. Vaninov, S.M. Akhunbaev, D.D. Ibraimova, N.M. Nasirova, O.A. Bolbachan

Abstract
Cervical cancer is one of the most important medical and social problems that cause enormous social and economic damage to society. The activities of medical institutions providing cancer care should be aimed at cancer prevention, timely detection, and treatment of cancer patients. The study used statistical data from the Health care Center, the National Center for Oncology and Hematology of the Kyrgyz Republic from 2012 to 2017. The study was conducted using a systematic approach, which consists of assessing the dynamics of the prevalence, structure, and dynamics of mortality from cervical cancer by age and region of the Kyrgyz Republic. The object of the study was women with a diagnosis of cervical cancer. The subject of study: appealability, the prevalence of incidence and mortality in women with this disease. Research method: statistical (intensive, extensive indicator, credibility, time series indicators, reliability criterion).


OPERATION BENTALL DE BONO AGAINST THE BACKGROUND OF BILATERAL POLYSEGMENTAL VIRAL PNEUMONIA (COVID-19) CASE FROM PRACTICE

S. Ahmed, I.Kh. Bebezov, M.K. Dzhundubaev, A.A. Rakimbaev, A.K. Turgunov, D.B. Toktosunova, I.A. Akhmedova, R.S. Kalieva, E.D. Seytakhunova

Abstract
Coronavirus-2 Severe Acute Respiratory Syndrome (SARS-CoV-2) was first described in early December 2019 and has rapidly spread globally, causing significant disruptions in the provision of healthcare services in many countries. The volume of cardiac surgery has also undergone significant changes due to the redistribution of bed resources. Although the measures applied have been beneficial for the treatment of patients with coronavirus infection (COVID-19), the implications of postponing cardiac surgery for patients with cardiovascular disease need to be considered. It can be assumed that these patients will have progression of the underlying disease, which will lead to an increase in the number of patients in need of emergency cardiac surgery. The article describes a case of emergency surgery in a patient with dissecting aneurysm of the aortic root on the background of bilateral polysegmental viral pneumonia   (COVID-19).
Key words: Covid-19, viral pneumonia, aortic aneurysm, multislice computed tomography (MSCT).


IMMUNOLOGICAL ASPECTS OF CYTOMEGALOVIRAL INFECTIONS AFTER PEDIATRIC LIVER TRANSPLANTATION

N.Zh. Erimova, Sh.K. Batyrkhanov, B.K. Shirtaev, B.B. Baimakhanov, A.T. Chormanov, S.D. Akilbekov, A.G. Akhbetova

Abstract
The article reflects the role of antiviral prophylaxis with valganciclovir or ganciclovir after pediatric liver transplantation. The study was conducted on the basis of data from thirty operations in children from 6 months to 8 years. All patients of our center with cytomegalovirus infection (CMV) received antiviral therapy for a month. In patients with active CMV, the viral load was reduced. Six months later, the quantitative     polymerase chain reaction (PCR) for CMV became negative in all patients. After nine (9) months, viral load increased in 1 (3.3%) patient with inactive CMV. After 12 (twelve) months, viremia was diagnosed in 6 (20%) patients and they were prescribed antiviral therapy for 3-6 months with valganciclovir. A decrease in the total number of T-lymphocytes and T-helpers was noted against the background of phylactic suppressive therapy and viremia (8 patients).


ASPECTS OF THE INFLUENCE OF CAVITATION PHENOMENA OF ULTRASONIC WAVES ON BIOLOGICAL OBJECTS AT DIFFERENT LEVELS OF TISSUE ORGANIZATION (LITERATURE REVIEW)

H.Z. Ahmedov, B.I. Nurdinov, A.V. Lysenko, A.T. Alymkulov

Abstract
Ultrasound is the most common diagnostic technique for many diseases with morphological substrates and pathological processes. Lack of control over the activities of ultrasound rooms, lack of knowledge about the physical properties of sound waves by the personnel, is a support for the development of remote consequences from a complex of factors associated with an ultrasound wave.
The article reflects the literature data and the likely influence of the effect of cavitation bubbles on the structural components of tissue cells. The blame is given to oncological processes and possible indirect effects on them.
Key words: cavitation, ultrasound, oncology, side effects.


ESTIMATION OF MORTALITY FROM BREAST CANCER IN KYRGYZSTAN

A.L. Chokoev, N.S. Igisinov

Abstract 
According to the International Agency for Research on Cancer, about 3 million new cases of breast cancer (BC) will be predicted in 2040, while it is expected that about 1 million women will die from this pathology.


OPHTHALMOLOGIC EXAMINATION AND STUDY OF VISUAL CONSEQUENCES IN CHILDREN WITH PRIMARY BRAIN TUMORS

K.B. Yrysov, B.A. Beknazarova, Alik kyzy E., N.A. Mamaziyaeva

Abstract  
Purpose of the work: To study the visual consequences of children with primary brain tumors who were sent for ophthalmological examination without a standard protocol.
Material and Methods: Medical records of all children (0-18 years old) with primary brain tumors were analyzed. In our institution, all children referred for ophthalmological examination were examined by pediatricians and / or neuro-ophthalmologists. For each patient, the following clinical data were collected: age at the time of tumor diagnosis, gender, pathologic diagnosis, major problems at initial presentation (including visual problems), tumor location, classification of surgical resection, treatment methods, and survival.
Humphrey visual field testing, optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL), and fundus color photographs were obtained from collaborating patients.
Results. A total of 141 patients (73 [52%] men; mean age [range 0-18] years) with primary brain tumors were included. There were 100 people who were recently diagnosed and 41 people who were examined for follow-up examination (brain tumor was diagnosed before enrollment in the study). The most common type of tumor was glioma, while other types of tumors (eg, ependymoma and atypical teratoid rhabdoid tumors) were less common. There were more patients with tumors of the parenchyma and fewer with tumors of the optic nerve and chiasm.
A decrease in visual acuity was observed in 37 patients (54%) in one or both eyes, of which 26 out of 68 (38%) had progressed amblyopia. Causes included deprivation (ptosis, keratopathy, and / or cataract) in 15 patients (58%), strabismus in 11 patients (42%), and refractive errors in 11 patients (42%). Exposure keratopathy due to palsy of the seventh cranial nerve was found in 10 patients (15%), of which 3 (30%) required aggressive treatment (tarsorrhaphy or corneal transplant).
Conclusion. The time has come for an interdisciplinary, integrated approach to the diagnosis and treatment of visual impairment in children with brain tumors. Given the significant advances in technology, OCT analysis of the retinal nerve fiber layer and ganglion cell complex in children under 3 years of age usually complements a thorough pediatric and / or neuro-ophthalmic assessment.
Key words : primary brain tumors, ophthalmological examination, decreased visual acuity, visual fields.


EARLY INTERVENTION IN THE SYSTEM OF REHABILITATION OF CHILDREN WITH SPEECH DELAYS

Arykpaeva Ch.S., Atykanov A.O.

Abstract 
The paper presents the results of early intervention in the rehabilitation of 26 children with speech development delay, conducted at the Specialized Center for the Rehabilitation of Children and the Family. It is shown that the measures taken made it possible to achieve the appearance of speech in 50% of children, and 19.2% of children had words and the exact pronunciation of words, as well as understanding of speech. This made it possible to ensure that 38.4% of children began to attend kindergartens, preschool institutions and 15.4% were socialized in the children's team.
Key words: children, early intervention, speech delay, rehabilitation.


ETIOLOGICAL AND CLINICAL ASPECTS OF PEDIATRIC STROKE

Kadyrova A. Sh., Atykanov A. O.

Abstract
The paper presents data from a survey of 21 children with a verified diagnosis of stroke, of which 14 children with ischaemic stroke and 7 children with bloodstroke. The survey was conducted in the interim 2014 - 2020 in the City clinical emergency hospital for children in Bishkek and in clinic Cortex. The average age of children was 5.3 ± 2.2 years. In 47.5.4% of stroke cases, the causes were not identified. The clinical symptoms were dominated by convulsions (52%) and hemiplegia (34%).
Key words: children, stroke, ischaemic stroke, bloodstroke.


ONLINE EDUCATION THROUGH THE EYES OF STUDENTS OF AZMI STUDENTS (BASED ON THE RESULTS OF THE TWO ONLINE SEMESTERS, 2020-SPRING AND FALL SEMESTERS)

Bakytbek B. Kulambaev

Abstract 
The sudden onset of the coronavirus (COVID-19) epidemic forced higher education institutions urgently switch to the online training format. In this research paper reflects the valuable experience of the transition to online education with the assessment of this form of education by the students themselves. Students themselves pointed out the advantages and disadvantages of online learning compared to offline and recommended ways to improve the educational process.
Key words: the COVID-19 pandemic; online education; online courses; quality of education; the satisfaction of students; higher education; internet.


CHANGES IN BIOCHEMICAL INDICATORS OF BLOOD UNDER THE INFLUENCE OF THE INSECTOACARICIDE BATONS ES

M.A. Marupova, Zh.T.Mamasaidov, Y.Kh.Nazarova

Abstract
This article discusses the negative effects of pesticides used in the gardens of the Ferghana Valley of the Republic of Uzbekistan. The composition and application of the insectoacaricide-Baton EC was studied. Much attention was paid to the hazards associated with the presence of residues in foodstuffs and other objects. The effect of Baton EC on the biochemical parameters of experimental animals was proved. A decrease in the synthesis or breakdown in total protein and an increase in nitrogen and pigment metabolism in the blood serum were revealed, which indicates a violation of the functional state of liver and kidneys in chronic insectoacaricide poisoning.
Keywords: pesticide, insectoacaricide, Baton, creatinine, bilirubin, ALT, AST, correction.


ENVIRONMENTAL IMPACT ON MATERNAL AND CHILD HEALTH

Zhanar Sabyrdilda, Ainur B. Kumar, Lyazzat Kosherbaeva

Abstract 
The World Health Organization named the goals for improving maternal health and determined the future direction of the and the Human Development Goals. Despite being expressed in the reduction of under-five mortality and high mortality rates, these causes fall short of achieving the goal.
Human health and well-being are determined by many complex factors. Maternal and child health encompasses the health and well-being of women, infants, children, adolescents and their families. Environmental factors have a direct impact on the health of various populations around the world, including maternal and child health as a result of exposure to chemicals in the air, water, soil, food and consumer products.


NTERACTIVE TEACHING METHODS IN THE PREPARATION OF MEDICAL

A.A. Abdumanonov

Abstract
The paper presents the goals and advantages of an interactive method of teaching medical students. The role of information technology in the modern educational process is huge and the informatization of the educational process is a reality of today and one of the best tools for training highly qualified medical personnel.  
Key words: interactive learning, learning technology, information technology in education, medical education, electronic educational resources.
 


COVID-19 VACCINATION DRIVE IN INDIA AND KYRGYZSTAN

Asma Ahad, M.A. Turdumambetova, Bhat Amir, Saifullah Baba


Abstract
Introduction. Both India and Kyrgyzstan are located in Asian continent. The countries have also experienced a huge loss of lives during COVID-19 pandemic. On 11 March 2020, when the outbreak was characterized as a pandemic putting normal life on hold for most people and overwhelming health care providers and then the year 2021 was mostly focused on vaccine distribution to put an end to the pandemic.
The aim of the present article is to learn about COVID-19 vaccination held in India and Kyrgyzstan (2020-22).


PROGNOSTIC VALUE OF OSTEOPROTEGERIN IN ASSESSING RISK OF CARDIOVASCULAR COMPLICATIONS AND OSTEOPOROTIC FRACTURES IN COMORBID PATHOLOGY

D. Sh. Chyngyshpaev, M. Kerimaly, A.M. Pasanova, A.T. Alymkulov, A.O. Uzakova, O.J. Uzakov

Abstract
Introduction. To study the predictive role of serum levels of osteoprotegerin (OPG) for risk stratification of adverse cardiovascular events and bone fractures in women with comorbid pathologies, including chronic heart failure (CHF), type 2 diabetes mellitus (DM 2) and osteoporosis.


COMORBID PATHOLOGY IN WOMEN WITH BENIGN AND MALIGNANT TUMORS OF THE UTERINE BODY

A.A. Firman1, A.V. Efremov1, O.J. Uzakov2, A.A. Masybaeva3

Abstract
The aim of the work was to analyze comorbid pathology in women with benign and malignant uterine diseases. 436 women were examined, of which the first group consisted of 101 patients diagnosed with uterine fibroids. The second group included 290 women with uterine body cancer. Control group - 45 healthy women of the sa age. Anamnestic, instrumental and laboratory research methods were used. In the group of sick women, significantly more frequent occurrence of gynecological pathology was revealed; the frequency of hypertension, chronic cholecystitis, obesity and type 2 diabetes mellitus was higher. The highest incidence of these somatic diseases was recorded in the group of women with uterine body cancer.
Keywords: cancer of the uterine body, uterine fibroids, comorbid pathology.


ANTIOXIDANT SYSTEM IN THE PATHOGENESIS OF TUMOR DISEASES (BY THE EXAMPLE OF FIBROIDS AND UTERINE CANCER)

A.A. Firman1, A.V. Efremov1, O.J. Uzakov2

Abstract
The aim of the study was to study the activity of the antioxidant system of the body in cancer patients, based on the content of fat-soluble antioxidants. 436 women were examined: 101 patients diagnosed with uterine fibroids; 290 women with uterine body cancer and 45 healthy women as controls. The content of -carotene, retinol and -tocopherol in blood serum was analyzed. It has been shown that in uterine cancer, unlike uterine fibroids, there is a more pronounced inhibition of the antioxidant system activity, expressed in a significant decrease in the levels of beta-carotene, retinol and -tocopherol in the blood. Conclusion: the inhibition of the antioxidant system activity in the mechanisms of development of tumor growth is beyond doubt. 
Keywords: uterine cancer, uterine fibroids, antioxidants, -carotene, retinol, -tocopherol.


CHOLERA IN INDIA AND KYRGYZSTAN

Tabindah Khursheed, Wani Farheen Mukhtar, М.А. Turdumambetova

Abstract
Introduction. Cholera is an acute, watery diarrheal disease caused by Vibrio cholera of the O1 or O139 serogroups usually spread through contaminated water and food. The disease causes severe diarrhea and dehydration. Left untreated, cholera can be fatal within hours. In the past two centuries, cholera has emerged and spread from the Ganges Delta six times and from Indonesia once to cause global pandemics. Modern sewage and water treatment have virtually eliminated cholera in industrialized countries. [1]