IMMUNOLOGICAL ASPECTS OF CYTOMEGALOVIRAL INFECTIONS AFTER PEDIATRIC LIVER TRANSPLANTATION

ERIMOVA N.ZH, BATYRKHANOV SH.K, SHIRTAEV B.K, BAIMAKHANOV B.B, CHORMANOV A.T, AKILBEKOV S.D, AKHBETOVA A.G.

Key words:

LIVER TRANSPLANTATION, CYTOMEGALOVIRUS INFECTION, PEDIATRIC TRANSPLANTATION

Abstract:

The article reflects the role of antiviral prophylaxis with valganciclovir or ganciclovir after pediatric liver transplantation. The study was conducted on the basis of data from thirty operations, in children from 6 months to 8 years. All patients of our center with cytomegalovirus infection (CMV) received antiviral therapy for a month. In patients with active CMV, the viral load was reduced. Six months later, the quantitative polymerase chain reaction (PCR) for CMV became negative in all patients. After nine (9) months, viral load increased in 1 (3.3%) patient with inactive CMV. After 12 (twelve) months, viremia was diagnosed in 6 (20%) patients and they were prescribed antiviral therapy for 3-6 months with valganciclovir. A decrease in the total number of T-lymphocytes and T-helpers was noted against the background of phylactic suppressive therapy and viremia (8 patients). Purpose : The purpose of this work is to assess the role of CMV infection in transplant immunology in children and the effect of CMV on the outcome of liver transplantation...