ANTIOXIDANT SYSTEM IN THE PATHOGENESIS OF TUMOR DISEASES (BY THE EXAMPLE OF FIBROIDS AND UTERINE CANCER)
A.A. Firman, A.V. Efremov, O.J. Uzakov
The aim of the study was to study the activity of the antioxidant system of the body in cancer patients, based on the content of fat-soluble antioxidants. 436 women were examined: 101 patients diagnosed with uterine fibroids; 290 women with uterine body cancer and 45 healthy women as controls. The content of - carotene, retinol and tocopherol in blood serum was analyzed. It has been shown that in uterine cancer, unlike uterine fibroids, there is a more pronounced inhibition of the antioxidant system activity, expressed in a significant decrease in the levels of beta-carotene, retinol and -tocopherol in the blood. Conclusion: the inhibition of the antioxidant system activity in the mechanisms of development of tumor growth is beyond doubt.
Keywords: uterine cancer, uterine fibroids, antioxidants, -carotene, retinol, -tocopherol.