ASSESSMENT OF THE PLASMA LIPID SYSTEM ADAPTIVE STRATEGIES BY DIFFERENTIAL ENTROPY MODELING USE
Chonkoeva A.A., Mukhamedova I.P.
Introduction. The lipid system of the blood is an example of a dynamic, open thermodynamic, stochastic system, which includes the following components: lipoproteins containing triacylglycerides, cholesterol and cholesterol esters, the state of which can be described by an entropy value and thus characterize the state of the like system as a whole.
The aim of the study is to consider the possibility of using differential-entropy mathematical modeling for stationary and dynamic adaptation of the lipid system and its components, as well as for the diagnosis of stressed and disadaptive states.
Materials and methods. There were 18 journal articles in Russian and 3 journal articles in English published at earliest in 2004; 3 dissertations, 10 national statistical sources and profiles, and 5 books were reviewed to present in the article.
Results. The study involved 120 students of medical universities in Kyrgyzstan (60 local and 60 foreign students). The control group was the indicators of the general population of healthy people of the corresponding age and gender. We selected the following laboratory-determined parameters of the lipid system for analysis - triacylglycerides (TG), high-density lipoproteins (HDL), total cholesterol (TC), while we excluded low-density lipoproteins (LDL) from the analysis, because it is determined by the calculation method according to the Friedwald’s formula based on the indicators of TC, TG and HDL. We used the techniques of entropy mathematical modeling presented in the O.M. Gerget’s (2011) and O.G. Berestneva (2014) study to assess the individual adaptation strategy of the students' lipid system. Integral criteria were used to calculate the degree of deviation of TG, TC and HDL values from the normal (from the value of the mathematical expectation of the reference (control) group and the permissible standard deviation).
Conclusions. An algorithm for lipid system adaptive strategies identification is given for diagnosing of four major adaptive behavior states: adaptive (normal), compensated (slightly tense), decompensated (tense) and disadaptive (overtense). Comparative analysis of identified strategies showed that adaptive behavior of lipid system and its components of foreign students are tenser than native student’s lipid system behavior. Analysis did not confirm ethnic specificity in adaptive strategies of lipid system as a whole, but confirm thin differences between male and female lipid system components adaptive response in both ethnic groups. The data confirm that physiological mechanisms of plasma lipid system rearrangement are common for different ethnic, but specific for sexual groups.
Key words: differential entropy, adaptation, plasma lipoproteins, foreign students.